Article
Mutation and expression analysis of corticotropin-releasing factor 1 receptor in adrenocorticotropin-secreting pituitary adenomas.
The Journal of clinical endocrinology and metabolism - 1 Sept 1998
Dieterich K D, Gundelfinger E D, Lüdecke D K, Lehnert H
Abstract excerpt
The present study was designed to investigate a possible role of CRF1 receptors (CRF1-R) in the pathogenesis of Cushing's disease. ACTH-secreting pituitary adenomas and nonsecreting pituitary adenomas have been analyzed for mutations in the CRF1-R gene by PCR and sequencing and been compared with...
Topics
- Adenoma
- Adrenocorticotropic Hormone
- Adult
- Aged
- Child
- DNA, Complementary
- Electrophoresis, Agar Gel
- Female
- Gene Expression
- Humans
- Male
- Middle Aged
- Mutation
- Pituitary Gland, Anterior
- Pituitary Neoplasms
- Polymerase Chain Reaction
- RNA, Messenger
- Receptors, Corticotropin-Releasing Hormone