Article
No evidence for oncogenic mutations in the adrenocorticotropin receptor gene in human adrenocortical neoplasms.
The Journal of clinical endocrinology and metabolism - 1 Mar 1995
Latronico A C, Reincke M, Mendonça B B, Arai K, Mora P, Allolio B, Wajchenberg B L, Chrousos G P, Tsigos C
Abstract excerpt
The mechanism(s) of tumorigenesis for the majority of adrenocortical neoplasms remain unknown. G-Protein-coupled receptors were recently proposed as candidate protooncogenes. That activating mutations of this class of receptors might be important for tumor induction or progression of endocrine ne...
Topics
- Adolescent
- Adrenal Cortex Neoplasms
- Adult
- Aged
- Base Sequence
- Child
- Female
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Receptors, Corticotropin