Article
No evidence for oncogenic mutations in the adrenocorticotropin receptor gene in human adrenocortical neoplasms.
The Journal of clinical endocrinology and metabolism - 1 Mar 1995
Latronico A C, Reincke M, Mendonça B B, Arai K, Mora P, Allolio B, Wajchenberg B L, Chrousos G P, Tsigos C
Abstract excerpt
The mechanism(s) of tumorigenesis for the majority of adrenocortical neoplasms remain unknown. G-Protein-coupled receptors were recently proposed as candidate protooncogenes. That activating mutations of this class of receptors might be important for tumor induction or progression of endocrine neoplasms was strengthened by the recent identification of such mutations in hyperfunctioning thyroid adenomas. To...
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