Article
Vasopressin receptors modulate the pharmacological phenotypes of Cushing's syndrome.
Endocrine research - 1 Jan 2000
Arnaldi G, de Keyzer Y, Gasc J M, Clauser E, Bertagna X
Abstract excerpt
We have examined the expression profiles of the different vasopressin receptors (V1, V2, V3) that can be expressed in the three different types of tumors associated with Cushing's syndrome. V3 (V1b) receptor cDNA was cloned from a pituitary tumor responsible for Cushing's disease. We show that it is overexpressed in these tumors and can respond to DD-AVP. High expression of the V3 receptor on highly...
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