Article
Expression of glucocorticoid receptor gene isoforms in corticotropin-secreting tumors.
The Journal of clinical endocrinology and metabolism - 1 Apr 1997
Dahia P L, Honegger J, Reincke M, Jacobs R A, Mirtella A, Fahlbusch R, Besser G M, Chew S L, Grossman A B
Abstract excerpt
The molecular basis of Cushing's disease is not known. One of the most characteristic features of such tumors is their resistance to corticosteroid feedback at the pituitary level. We have hypothesized that abnormalities of the glucocorticoid receptor (GR) gene might play a role in the development of Cushing's disease via an increase in the relative production of the nonligand-binding splice variant of the GR, GR...
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