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Article

Absence of somatic mutations in natriuretic peptide receptor type A gene in human aldosterone-secreting adenomas.

Journal of molecular endocrinology - 1 Oct 2003

Sarzani R, Salvi F, Pietrucci F, Buglia L, Candelaresi C, Balducci B, Francioni M, Fazioli F, Letizia C, D'Erasmo E, Dessì-Fulgheri P, Rappelli A

Abstract excerpt

Somatic mutations of genes codifying for key regulatory proteins are the cause of different types of hormone-secreting adenomas. Natriuretic peptides (NP) are the strongest inhibitors of aldosterone secretion but aldosterone-secreting adenomas (aldosteronomas) are resistant to this inhibition and have reduced binding sites for NPs. The objective of this study was to sequence the entire coding region of the NP...

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Identifiers

PMID: 14519099
DOI: 10.1677/jme.0.0310317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of somatic mutations in natriuretic peptide receptor type A gene in human aldosterone-secreting adenomas.PMID 14519099Read ↗

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