Absence of activating mutations in the GnRH receptor gene in human pituitary gonadotroph adenomas.

doi:10.1530/eje.0.1390157

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Article

Absence of activating mutations in the GnRH receptor gene in human pituitary gonadotroph adenomas.

European journal of endocrinology - 1 Aug 1998

Chanson P, De Roux N, Young J, Bidart J M, Jacquet P, Misrahi M, Milgrom E, Schaison G

Abstract excerpt

The monoclonal origin of gonadotropin-secreting pituitary adenomas has been well demonstrated but only few molecular abnormalities have so far been recognized in these tumors. For many years, several authors have suggested a role for GnRH and/or GnRH receptors (GnRH-R) in the development of these...

Topics

Adenoma
Adult
Aged
Female
Gonadotropins, Pituitary
Humans
Immunohistochemistry
Male
Middle Aged
Mutation
Pituitary Neoplasms
Receptors, LHRH
Sequence Analysis, DNA

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