Article
Absence of activating mutations in the GnRH receptor gene in human pituitary gonadotroph adenomas.
European journal of endocrinology - 1 Aug 1998
Chanson P, De Roux N, Young J, Bidart J M, Jacquet P, Misrahi M, Milgrom E, Schaison G
Abstract excerpt
The monoclonal origin of gonadotropin-secreting pituitary adenomas has been well demonstrated but only few molecular abnormalities have so far been recognized in these tumors. For many years, several authors have suggested a role for GnRH and/or GnRH receptors (GnRH-R) in the development of these pituitary adenomas. To test the hypothesis that mutant genes encoding a constitutively activated GnRH-R might be...
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