Article
Overexpression of vasopressin (V3) and corticotrophin‐releasing hormone receptor genes in corticotroph tumours
1 Oct 1998
Abstract excerpt
OBJECTIVE: The molecular mechanisms underlying ACTH-secreting tumour formation remain unknown. Transmembrane signalling pathways play an important role in several endocrine disorders including pituitary tumours. To investigate the role of the pituitary vasopressin (V3) receptor (R) in ACTH-secreting tumours we have qualitatively and quantitatively analysed its mRNA. DESIGN: RT-PCR, denaturing gradient gel...
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