Article
Are activating mutations of the adrenocorticotropin receptor involved in adrenal cortical neoplasia?
Life sciences - 1 Jan 1995
Light K, Jenkins P J, Weber A, Perrett C, Grossman A, Pistorello M, Asa S L, Clayton R N, Clark A J
Abstract excerpt
The objective of this study was to investigate the presence of activating mutations of the ACTH receptor gene in benign and malignant adrenocortical tumours. Genomic DNA was extracted from a variety of adrenocortical neoplasms from 16 patients and the entire ACTH receptor gene was then amplified...
Topics
- Adenoma
- Adolescent
- Adrenal Cortex Neoplasms
- Adult
- Blotting, Northern
- Child, Preschool
- Cushing Syndrome
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Receptors, Corticotropin