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Article

Menin mutations in patients with multiple endocrine neoplasia type 1

1 Dec 1997

Abstract excerpt

Multiple endocrine neoplasia type 1 (MEN-1) is a familial cancer syndrome with parathyroid, pituitary and enteropancreatic tumors. The disease phenotype segregates with markers on chromosome 11q13. Very recently a new gene was cloned from this region and was found to carry mutations in 14 of 15 unrelated MEN-1 patients. The gene was termed menin and is predicted to code for a tumor suppressor protein of 610 amino...

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Identifiers

PMID: 9437237
DOI: 10.1530/eje.0.1370684

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