Article
A male-specific increase in the HLA-DRB4 (DR53) frequency in high-risk and relapsed childhood ALL.
Leukemia research - 1 Jul 2002
Dorak M Tevfik, Oguz Fatma S, Yalman Nevin, Diler A Sarper, Kalayoglu Sevgi, Anak Sema, Sargin Deniz, Carin Mahmut
Abstract excerpt
Previous studies reported significant HLA-DR associations with various leukemias one of which is with HLA-DRB4 (DR53) family in male patients with childhood ALL. We have HLA-DR-typed 212 high-risk or relapsed patients with childhood (n=114) and adult (n=98) ALL and a total of 250 healthy controls (118 children, 132 adult) by PCR-SSP analysis. The members of the HLA-DRB3 (DR52) family were underrepresented in...
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