Article
p53 mutagenesis in Klatskin tumors.
Human pathology - 1 Sept 1998
Jonas S, Springmeier G, Tauber R, Wiedenmann B, Lobeck H, Gessner R, Kreft B, Kling N, Moelling K, Neuhaus P
Abstract excerpt
Mutagenesis of the p53 tumor-suppressor gene represents the most common genetic alteration in human malignancies but has not yet been investigated in Klatskin tumors. Cancerous and normal liver tissues were obtained from 12 patients after surgical resection of Klatsin tumors. Genomic DNA was extr...
Topics
- Adult
- Aged
- Bile Duct Neoplasms
- DNA, Neoplasm
- Female
- Genes, p53
- Hepatic Duct, Common
- Humans
- Klatskin Tumor
- Male
- Middle Aged
- Mutation