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Article

p53 mutagenesis in Klatskin tumors.

Human pathology - 1 Sept 1998

Jonas S, Springmeier G, Tauber R, Wiedenmann B, Lobeck H, Gessner R, Kreft B, Kling N, Moelling K, Neuhaus P

Abstract excerpt

Mutagenesis of the p53 tumor-suppressor gene represents the most common genetic alteration in human malignancies but has not yet been investigated in Klatskin tumors. Cancerous and normal liver tissues were obtained from 12 patients after surgical resection of Klatsin tumors. Genomic DNA was extracted and served as a template for PCR amplification and sequencing of a 1,574-bp fragment of the p53 gene comprising...

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PMID: 9744311
DOI: 10.1016/s0046-8177(98)90200-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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