Article
Restricted polymorphism of the mannose-binding lectin gene of indigenous Australians.
Human molecular genetics - 12 Jun 2000
Turner M W, Dinan L, Heatley S, Jack D L, Boettcher B, Lester S, McCluskey J, Roberton D
Abstract excerpt
Mannose-binding lectin (MBL) is an important complement-activating protein of the human innate immune system. Deficiency of MBL is associated with an increased risk of various infections and arises from three structural gene mutations in exon 1 (variants B, C and D) and/or the presence of a low efficiency promoter. The C allele is found in sub-Saharan Africa whereas the B allele is found elsewhere, suggesting...
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