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Article

Cancer Gene Therapy Using a Replication-Competent Herpes Simplex Virus Type 1 Vector

1 Sept 1998

Abstract excerpt

OBJECTIVE: The authors investigate the efficacy of hrR3, a viral vector derived from herpes simplex virus type 1 (HSV 1), in destroying colon carcinoma cells in vitro and in vivo. The effect of adding the prodrug ganciclovir in combination with hrR3 infection also is assessed. SUMMARY BACKGROUND DATA: Most cancer gene therapy strategies use viral vectors that are incapable of replication. The HSV 1 vector hrR3 is...

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PMID: 9742919
DOI: 10.1097/00000658-199809000-00009

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