Article
KRAS(D13) Promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand.
Cancer research - 15 May 2006
Smakman Niels, van den Wollenberg Diana J M, Elias Sjoerd G, Sasazuki Takehiko, Shirasawa Senji, Hoeben Rob C, Borel Rinkes Inne H M, Kranenburg Onno
Abstract excerpt
Colorectal tumors frequently contain activating mutations in KRAS. ReovirusT3D is an oncolytic virus that preferentially kills tumor cells with an activated Ras pathway. Here we have assessed the contribution of endogenous mutant KRAS in human colorectal cancer cell lines to ReovirusT3D replication and to tumor cell oncolysis. In addition, treatment combinations involving ReovirusT3D, oxaliplatin, and tumor...
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