Article
Immunosuppression promotes reovirus therapy of colorectal liver metastases.
Cancer gene therapy - 1 Aug 2006
Smakman N, van der Bilt J D W, van den Wollenberg D J M, Hoeben R C, Borel Rinkes I H M, Kranenburg O
Abstract excerpt
Mortality due to colorectal cancer (CRC) is high and is associated with the development of liver metastases. Approximately 40% of human CRCs harbor an activating mutation in the KRAS oncogene. Tumor cells with activated KRAS are particularly sensitive to Reovirus T3D, a non-pathogenic oncolytic virus. The efficacy of virus-based therapies may be positively or negatively modulated by the host immune system. This...
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