Treatment of malignant gliomas using ganciclovir-hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant.

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Article

Treatment of malignant gliomas using ganciclovir-hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant.

Cancer research - 1 Aug 1994

Mineta T, Rabkin S D, Martuza R L

Abstract excerpt

We have demonstrated that attenuated mutants of herpes simplex virus (HSV) have therapeutic potential for malignant brain tumors. In this report, we tested a ribonucleotide reductase-deficient (RR-) HSV mutant as an experimental treatment for malignant brain tumors. The HSV-RR- mutant hrR3, containing an Escherichia coli lacZ gene insertion in the ICP6 gene that encodes the large subunit of RR, was used in this...

Topics

Animals
Brain Neoplasms
Cytopathogenic Effect, Viral
Drug Resistance
Female
Ganciclovir
Genetic Therapy
Glioblastoma
Humans
Mice
Mice, Inbred BALB C
Mice, Nude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Random Allocation

Ribonucleotide Reductases

Simplexvirus

Tumor Cells, Cultured

Vero Cells

Source

Open in PubMed

Identifiers

PMID: 8033122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8033122-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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