Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of the antitumor effects of Herpes simplex virus lacking ribonucleotide reductase in a murine retinoblastoma model.

Current eye research - 1 Jan 2000

Cullinan Amy E, Lindstrom Mary J, Sabet Sina, Albert Daniel M, Brandt Curtis R

Abstract excerpt

PURPOSE: To determine if an attenuated herpes simplex virus (HSV) lacking the large subunit of ribonucleotide reductase has antitumor effects in a transgenic mouse model of retinoblastoma (LHbetaTAg). METHODS: LHbetaTAg mice were injected ocularly with 1 x 10(6) pfu of the hrR3 virus and tumor sizes were measured 3 weeks later. Replication of the virus in the eye and cultured murine retinoblastoma cells was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to Mice, Inbred Strains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Retinal Neoplasms

Share to Retinoblastoma

Share to Ribonucleotide Reductases

Share to Simplexvirus

Share to Vero Cells

Share to Viruses

Source

Identifiers

PMID: 15512963
DOI: 10.1080/02713680490504894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of the antitumor effects of Herpes simplex virus lacking ribonucleotide reductase in a murine retinoblastoma model.PMID 15512963Read ↗

Mutant herpes simplex virus-mediated suppression of retinoblastoma.Semantic proximity Read ↗

Treatment of malignant gliomas using ganciclovir-hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant.Semantic proximity Read ↗

Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase.Semantic proximity Read ↗

Cancer Gene Therapy Using a Replication-Competent Herpes Simplex Virus Type 1 VectorSemantic proximity Read ↗

Experimental gene therapy for an in vitro model of proliferative vitreoretinopathy.Semantic proximity Read ↗

Therapeutic Efficiency and Safety of a Second-Generation Replication-Conditional HSV1 Vector for Brain Tumor Gene TherapySemantic proximity Read ↗

Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats.Semantic proximity Read ↗

Deletion of the herpes simplex virus type 1 ribonucleotide reductase gene alters virulence and latency in vivo.Semantic proximity Read ↗

The herpes simplex virus type 1 ribonucleotide reductase is required for acute retinal disease.Semantic proximity Read ↗

Widespread intratumoral virus distribution with fractionated injection enables local control of large human rhabdomyosarcoma xenografts by oncolytic herpes simplex viruses.Semantic proximity Read ↗

An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma.Semantic proximity Read ↗

Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral VectorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.