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Article

An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2000

Yoon S S, Nakamura H, Carroll N M, Bode B P, Chiocca E A, Tanabe K K

Abstract excerpt

Viruses used for gene therapy are usually genetically modified to deliver therapeutic transgenes and prevent viral replication. In contrast, replication-competent viruses may be used for cancer therapy because replication of some viruses within cancer cells can result in their destruction (oncolysis). Viral ribonucleotide reductase expression is defective in the HSV1 mutant hrR3. Cellular ribonucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10657986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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