Article
Topical and oral administration of the natural water-soluble antioxidant from spinach reduces the multiplicity of papillomas in the Tg.AC mouse model.
Toxicology letters - 31 May 2001
Nyska A, Lomnitski L, Spalding J, Dunson D B, Goldsworthy T L, Ben-Shaul V, Grossman S, Bergman M, Boorman G
Abstract excerpt
The Tg.AC mouse carrying the v-Ha-ras structural gene is a useful model for the study of chemical carcinogens, especially those acting via non-genotoxic mechanisms. This study evaluated the efficacy of the non-toxic, water-soluble antioxidant from spinach, natural antioxidant (NAO), in reducing skin papilloma induction in female hemizygous Tg.AC mice treated dermally five times over 2.5 weeks with 2.5 microg...
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