Article
Factor binding to the human gamma-globin gene distal CCAAT site: candidates for repression of the normal gene or activation of HPFH mutants.
British journal of haematology - 1 Sept 1998
Partington G A, Patient R K
Abstract excerpt
We have examined factor binding to the distal human gamma-globin CCAAT site and three naturally occurring hereditary persistence of fetal haemoglobin (HPFH) mutations of this site. Factor binding was examined using nuclear extracts from the erythroleukaemic cell lines K562 and MEL, and from A4 ce...
Topics
- Animals
- Base Sequence
- Binding, Competitive
- Butyrates
- Butyric Acid
- DNA
- DNA-Binding Proteins
- Electrophoresis
- Fetal Hemoglobin
- GATA2 Transcription Factor
- Globins
- Hemin
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Repressor Proteins
- Salmon