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Article

Factor binding to the human gamma-globin gene distal CCAAT site: candidates for repression of the normal gene or activation of HPFH mutants.

British journal of haematology - 1 Sept 1998

Partington G A, Patient R K

Abstract excerpt

We have examined factor binding to the distal human gamma-globin CCAAT site and three naturally occurring hereditary persistence of fetal haemoglobin (HPFH) mutations of this site. Factor binding was examined using nuclear extracts from the erythroleukaemic cell lines K562 and MEL, and from A4 cells, a non-transformed mouse bone marrow stem cell line, using the electrophoretic mobility shift assay. Under standard...

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Identifiers

PMID: 9734644
DOI: 10.1046/j.1365-2141.1998.00849.x

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