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Article

Developmentally specific role of the CCAAT box in regulation of human gamma-globin gene expression.

The Journal of biological chemistry - 13 Feb 2004

Fang Xiangdong, Han Hemei, Stamatoyannopoulos George, Li Qiliang

Abstract excerpt

The CCAAT box is a widespread motif in eukaryotic promoters. In this study we demonstrate that the effects of the CCAAT box on gamma-globin gene activation are developmentally distinct. Although this promoter element is essential for high level gamma gene expression in adult erythropoiesis, it plays little role in embryonic erythroid cells. The CCAAT mutation in the human gamma-globin gene promoter impairs...

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Identifiers

PMID: 14645237
DOI: 10.1074/jbc.M306241200
PMCID: PMC2808414

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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