A role for the distal CCAAT box of the gamma-globin gene in Hb switching.

doi:10.1093/oxfordjournals.jbchem.a124723

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Article

A role for the distal CCAAT box of the gamma-globin gene in Hb switching.

Journal of biochemistry - 1 Jan 1995

Katsube T, Fukumaki Y

Abstract excerpt

Hereditary persistence of fetal hemoglobin (HPFH) is a condition manifested by continued expression of the gamma-globin gene in adult life. The four types of HPFH mutations (-117 G-A, -114 C-T, -114 C-G, and 13 bp del) clustered in the vicinity of the distal CCAAT box of the gamma-globin gene sug...

Topics

Base Sequence
Cell Line
Erythroid Precursor Cells
Fetal Hemoglobin
Genes, Switch
Globins
Humans
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Promoter Regions, Genetic
Transcriptional Activation

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