Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals.

Blood - 15 Sept 1998

Tournamille C, Le Van Kim C, Gane P, Le Pennec P Y, Roubinet F, Babinet J, Cartron J P, Colin Y

Abstract excerpt

The Duffy (FY) blood group antigens are carried by the DARC glycoprotein, a widely expressed chemokine receptor. The molecular basis of the Fya/Fyb and Fy(a-b-) polymorphisms has been clarified, but little is known about the Fyx antigen and the FY*X allele associated with weak expression of Fyb,...

Topics

Alleles
Amino Acid Substitution
Animals
Antigens, Protozoan
Arginine
Blood Grouping and Crossmatching
Blotting, Western
COS Cells
Carrier Proteins
Cysteine
Duffy Blood-Group System
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoantibodies

Membrane Proteins

Molecular Sequence Data

Mutation

Protozoan Proteins

Receptors, Cell Surface

Source

Open in PubMed

Identifiers

PMID: 9731074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9731074-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals.PMID 9731074Read ↗

The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein.Semantic proximity Read ↗

A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype.Semantic proximity Read ↗

Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fya/Fyb antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a-b-) phenotype.Semantic proximity Read ↗

Molecular mechanisms that lead to reduced expression of duffy antigens.Semantic proximity Read ↗

A novel FY*A allele with the 265T and 298A SNPs formerly associated exclusively with the FY*B allele and weak Fy(b) antigen expression: implication for genotyping interpretative algorithms.Semantic proximity Read ↗

The Duffy blood group system: a review.Semantic proximity Read ↗

New genotypes in Fy(a-b-) individuals: nonsense mutations (Trp to stop) in the coding sequence of either FY A or FY B.Semantic proximity Read ↗

Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals.Semantic proximity Read ↗

Molecular basis of the Duffy blood group system.Semantic proximity Read ↗

[Duffy blood group antigens: structure, serological properties and function].Semantic proximity Read ↗

A novel FY allele in Brazilians.Semantic proximity Read ↗

A clinically applicable method for determining the three major alleles at the Duffy (FY) blood group locus using polymerase chain reaction with allele-specific primers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.