Article
Molecular mechanisms that lead to reduced expression of duffy antigens.
Transfusion - 1 Mar 2000
Yazdanbakhsh K, Rios M, Storry J R, Kosower N, Parasol N, Chaudhuri A, Reid M E
Abstract excerpt
BACKGROUND: In the Duffy blood group system, the null phenotype Fy(a-b-) has been classically associated with a mutated GATA box, while the Fy(x) phenotype weak Fy(b) is associated with Arg89Cys and Ala100Thr mutations. This report assesses the prevalence of the Duffy GATA box and the Fy(x)-associated mutations in white and African American (black) donors and investigates the molecular mechanism underlying the...
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