Article
A novel FY allele in Brazilians.
Vox sanguinis - 1 Oct 2004
Castilho L, Rios M, Pellegrino J, Saad S T O, Costa F F, Reid M E
Abstract excerpt
The GATA box single nucleotide polymorphism (SNP) at position -33 (T>C) in Blacks silences the expression of FY*B in erythrocytes, and the substitution 265 C>T, together with 298 G>A, weakens the Fy(b) antigen (Fy(x)). Individuals with these phenotypes/genotypes who receive Fy(b+) blood are unlikely to be alloimmunized to Fy(b) because, in the presence of 265 T, the Fy(b) antigen is expressed, and in the case of...
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