The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein.

doi:10.1046/j.1365-2141.1998.01083.x

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Article

The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein.

British journal of haematology - 1 Dec 1998

Olsson M L, Smythe J S, Hansson C, Poole J, Mallinson G, Jones J, Avent N D, Daniels G

Abstract excerpt

The molecular basis of the three major alleles (Fy(a)/Fy(b)/Fy) of the Duffy (FY) blood group system has recently been established but the Fy(x) phenotype associated with weak expression of the Fy(b) and other FY antigens is poorly understood. In the Fy(x) genes of five unrelated British and Swed...

Topics

Alleles
Duffy Blood-Group System
Flow Cytometry
Humans
Mutation, Missense
Phenotype
Polymerase Chain Reaction
Sequence Analysis, DNA

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