Article
p53, mutations, and apoptosis in genistein-exposed human lymphoblastoid cells.
Mutation research - 31 Aug 1998
Morris S M, Chen J J, Domon O E, McGarrity L J, Bishop M E, Manjanatha M G, Casciano D A
Abstract excerpt
The phytoestrogen, genistein, is a naturally occurring isoflavone found in soy products. On a biochemical basis, genistein is a competitive inhibitor of tyrosine kinases and the DNA synthesis-related enzyme, topoisomerase-II (topo-II). Exposure of mammalian cells to genistein results in DNA damag...
Topics
- Apoptosis
- Carcinogens
- Cell Cycle
- Cell Survival
- Cells, Cultured
- Clone Cells
- Flow Cytometry
- Genes, p53
- Genistein
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Micronucleus Tests
- Mutagenicity Tests
- Mutagens
- Mutation
- Thioguanine
- Trifluridine