Article
Genotoxicity and carcinogenicity studies of soy isoflavones.
International journal of toxicology - 1 Jan 2000
Misra R R, Hursting S D, Perkins S N, Sathyamoorthy N, Mirsalis J C, Riccio E S, Crowell J A
Abstract excerpt
The potential cancer preventive efficacy of soy isoflavones is being investigated in preclinical and phase 1 clinical studies sponsored by the U.S. National Cancer Institute. Although 90-day oral toxicity studies with PTI G-2535 (an investigational soy isoflavone drug product) in rats and dogs, as well as teratology studies, indicated no signs of toxicity, there remains a mechanistic concern associated with the...
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