Article
Evaluation of the genotoxicity of the phytoestrogen, coumestrol, in AHH-1 TK(+/-) human lymphoblastoid cells.
Mutation research - 1 Mar 2001
Domon O E, McGarrity L J, Bishop M, Yoshioka M, Chen J J, Morris S M
Abstract excerpt
Coumestrol, a phytoestrogen found in high levels in alfalfa and red clover, is of concern since endocrine disorders have been observed in farm animals exposed to high levels of phytoestrogens. Previous studies found that coumestrol was an effective inducer of DNA strand breaks, micronuclei, and mutations in the Hypoxanthine phosphoribosyl transferase (HPRT) gene of Chinese hamster ovary cells. In the experiments...
Topics
- Base Sequence
- Cell Death
- Cell Line
- Clone Cells
- Coumestrol
- DNA Primers
- Evaluation Studies as Topic
- Humans
- Loss of Heterozygosity
- Lymphocytes
- Micronucleus Tests
- Mutation
- Thymidine Kinase