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Article

Cell-cycle arrest and inhibition of G1 cyclin translation by iron in AFT1-1(up) yeast.

The EMBO journal - 1 Sept 1998

Philpott C C, Rashford J, Yamaguchi-Iwai Y, Rouault T A, Dancis A, Klausner R D

Abstract excerpt

Although iron is an essential nutrient, it is also a potent cellular toxin, and the acquisition of iron is a highly regulated process in eukaryotes. In yeast, iron uptake is homeostatically regulated by the transcription factor encoded by AFT1. Expression of AFT1-1(up), a dominant mutant allele, results in inappropriately high rates of iron uptake, and AFT1-1(up) mutants grow slowly in the presence of high...

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Identifiers

PMID: 9724638
DOI: 10.1093/emboj/17.17.5026
PMCID: PMC1170830

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