Article
Cell-cycle arrest and inhibition of G1 cyclin translation by iron in AFT1-1(up) yeast.
The EMBO journal - 1 Sept 1998
Philpott C C, Rashford J, Yamaguchi-Iwai Y, Rouault T A, Dancis A, Klausner R D
Abstract excerpt
Although iron is an essential nutrient, it is also a potent cellular toxin, and the acquisition of iron is a highly regulated process in eukaryotes. In yeast, iron uptake is homeostatically regulated by the transcription factor encoded by AFT1. Expression of AFT1-1(up), a dominant mutant allele,...
Topics
- Biological Transport
- Cyclins
- Fungal Proteins
- G1 Phase
- Gene Expression Regulation, Fungal
- Homeostasis
- Iron
- Models, Genetic
- Mutation
- Protein Biosynthesis
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription Factors
- Tripeptidyl-Peptidase 1