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Article

Molecular basis of force-pCa relation in MYL2 cardiomyopathy mice: Role of the super-relaxed state of myosin.

Proceedings of the National Academy of Sciences of the United States of America - 22 Feb 2022

Yuan Chen-Ching, Kazmierczak Katarzyna, Liang Jingsheng, Ma Weikang, Irving Thomas C, Szczesna-Cordary Danuta

Abstract excerpt

In this study, we investigated the role of the super-relaxed (SRX) state of myosin in the structure-function relationship of sarcomeres in the hearts of mouse models of cardiomyopathy-bearing mutations in the human ventricular regulatory light chain (RLC, MYL2 gene). Skinned papillary muscles from hypertrophic (HCM-D166V) and dilated (DCM-D94A) cardiomyopathy models were subjected to small-angle X-ray diffraction...

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Identifiers

PMID: 35177471
DOI: 10.1073/pnas.2110328119
PMCID: PMC8872785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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