The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and [Ca 2+ ]

doi:10.1113/jp286802

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Article

The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and [Ca 2+ ]

16 Sept 2024

Abstract excerpt

Abstract Precise regulation of sarcomeric contraction is essential for normal cardiac function. The heart must generate sufficient force to pump blood throughout the body, but either inadequate or excessive force can lead to dysregulation and disease. Myosin regulatory light chain (RLC) is a thick‐filament protein that binds to the neck of the myosin heavy chain. Post‐translational phosphorylation of RLC (RLC‐P)...

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PMID: 39283968
DOI: 10.1113/jp286802

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