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Article

Spontaneous seroconversion in chronic hepatitis B: role of mutations in the precore/core gene.

Digestive diseases and sciences - 1 Aug 1998

Schulte-Frohlinde E, Foster G R

Abstract excerpt

The mechanism underlying spontaneous clearance of hepatitis B e antigen (HBeAg) and the appearance of antibodies (anti-HBe seroconversion) in chronic hepatitis B is not known. Previous studies have demonstrated mutations within the precore/core gene before, during, and after seroconversion, suggesting that the emergence of mutations in the core gene may abrogate tolerance and that this event may act as a general...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9724158
DOI: 10.1023/a:1018871300703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Spontaneous seroconversion in chronic hepatitis B: role of mutations in the precore/core gene.PMID 9724158Read ↗

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Nucleotide sequence analysis of the precore region in patients with spontaneous reactivation of chronic hepatitis B.Semantic proximity Read ↗

Evolution of precore/core promoter mutations in hepatitis B carriers with hepatitis B e antigen seroreversion.Semantic proximity Read ↗

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Changes in the hepatitis B virus precore and core regions in association with the disappearance of hepatitis B e antigen in patients with chronic hepatitis B.Semantic proximity Read ↗

Hepatitis B e antigen negative chronic active hepatitis: hepatitis B virus core mutations occur predominantly in known antigenic determinants.Semantic proximity Read ↗

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