Spontaneous seroconversion in chronic hepatitis B: role of mutations in the precore/core gene.

doi:10.1023/a:1018871300703

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Article

Spontaneous seroconversion in chronic hepatitis B: role of mutations in the precore/core gene.

Digestive diseases and sciences - 1 Aug 1998

Schulte-Frohlinde E, Foster G R

Abstract excerpt

The mechanism underlying spontaneous clearance of hepatitis B e antigen (HBeAg) and the appearance of antibodies (anti-HBe seroconversion) in chronic hepatitis B is not known. Previous studies have demonstrated mutations within the precore/core gene before, during, and after seroconversion, sugge...

Topics

Adult
Hepatitis B Antibodies
Hepatitis B Core Antigens
Hepatitis B e Antigens
Hepatitis B virus
Hepatitis B, Chronic
Humans
Male
Middle Aged
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational

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