Article
Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with interferon therapy.
Hepatology (Baltimore, Md.) - 1 Dec 1990
Takeda K, Akahane Y, Suzuki H, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M
Abstract excerpt
Hepatitis B virus DNA clones were propagated from sera of six patients with chronic hepatitis B who seroconverted from HBeAg to antibody to HBeAg either spontaneously or after administration of alpha-interferon. Defects in the precore region blocking synthesis and secretion of HBeAg were detected...
Topics
- Adult
- Amino Acid Sequence
- Base Sequence
- Chronic Disease
- DNA, Viral
- Female
- Hepatitis B
- Hepatitis B Antibodies
- Hepatitis B e Antigens
- Hepatitis B virus
- Humans
- Interferon Type I
- Middle Aged
- Molecular Sequence Data
- Mutation
- Recurrence