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Article

Cumulative viral evolutionary changes in chronic hepatitis B virus infection precedes hepatitis B e antigen seroconversion.

Gut - 1 Sept 2013

Cheng Yan, Guindon Stephane, Rodrigo Allen, Wee Lin Ying, Inoue Masafumi, Thompson Alex J V, Locarnini Stephen, Lim Seng Gee

Abstract excerpt

OBJECTIVE: To examine viral evolutionary changes and their relationship to hepatitis B e antigen (HBeAg) seroconversion. DESIGN: A matched case-control study of HBeAg seroconverters (n = 8) and non-seroconverters (n = 7) with adequate stored sera before seroconversion was performed. Nested PCR, cloning and sequencing of hepatitis B virus (HBV) precore/core gene was performed. Sequences were aligned using Clustal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23242209
DOI: 10.1136/gutjnl-2012-302408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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