Article
Hepatitis B e antigen negative chronic active hepatitis: hepatitis B virus core mutations occur predominantly in known antigenic determinants.
Journal of viral hepatitis - 1 Jan 1995
Carman W F, Thursz M, Hadziyannis S, McIntyre G, Colman K, Gioustoz A, Fattovich G, Alberti A, Thomas H C
Abstract excerpt
In chronic hepatitis B virus (HBV) infection seroconversion from hepatitis B e antigen (HBeAg) to hepatitis B e antibody (HBeAb) may be followed either by remission of the disease with low-level viraemia, or by continuing inflammation with high-level viraemia. In both situations the virus may acquire a mutation in the precore sequence which prevents it from encoding HBeAg. We now show that the number of amino...
Topics
- CD4-Positive T-Lymphocytes
- Epitopes
- Hepatitis B e Antigens
- Hepatitis B virus
- Hepatitis, Chronic
- Humans
- Mutation
- Viral Core Proteins