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Article

Nucleotide sequence analysis of the precore region in patients with spontaneous reactivation of chronic hepatitis B.

Digestive diseases and sciences - 1 Sept 1994

Laskus T, Rakela J, Tong M J, Persing D H

Abstract excerpt

The role of HBV precore mutations in the spontaneous reactivation of chronic hepatitis B (CHB) is currently unknown. We studied 10 patients with CHB; five were HBeAg+ (group I) and five were anti-HBe+ (group II). All 10 had spontaneous reactivation of CHB as defined by the appearance of clinical symptoms along with an increase of serum ALT activity at least 5X above baseline values, in the absence of any other...

Topics

Adult
Base Sequence
DNA, Viral
Female
Gene Amplification
Hepatitis B
Hepatitis B Antibodies
Hepatitis B e Antigens
Hepatitis B virus
Hepatitis, Chronic
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Mutation

Sequence Analysis, DNA

Source

Identifiers

PMID: 8082510
DOI: 10.1007/BF02088138

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8082510-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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