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Article

Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells.

The Journal of biological chemistry - 9 May 2003

Kishimoto Hiroyuki, Nakagawa Kentaro, Watanabe Tomomi, Kitagawa Daiju, Momose Haruka, Seo Jungwon, Nishitai Gen, Shimizu Nao, Ohata Shinya, Tanemura Shuhei, Asaka Satoshi, Goto Takayuki, Fukushi Hiromichi, Yoshida Hiroki, Suzuki Akira, Sasaki Takehiko, Wada Teiji, Penninger Josef M, Nishina Hiroshi, Katada Toshiaki

Abstract excerpt

Stress-activated protein kinase/c-Jun NH(2)-terminal kinase (SAPK/JNK), belonging to the mitogen-activated protein kinase family, plays an important role in stress signaling. SAPK/JNK activation requires the phosphorylation of both Thr and Tyr residues in its Thr-Pro-Tyr motif, and SEK1 and MKK7 have been identified as the dual specificity kinases. In this study, we generated mkk7(-/-) mouse embryonic stem (ES)...

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Identifiers

PMID: 12624093
DOI: 10.1074/jbc.M213182200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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