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Article

Palmitoylation of a G protein alpha i subunit requires membrane localization not myristoylation.

The Journal of biological chemistry - 9 Dec 1994

Degtyarev M Y, Spiegel A M, Jones T L

Abstract excerpt

Palmitoylation is a dynamic, post-translational modification of the amino terminus of heterotrimeric G protein alpha subunits. Since myristoylation, beta gamma interactions, and membrane attachment also involve the amino terminus of the G protein alpha i1 subunit, we studied the relationships between palmitoylation and these events. Using COS cell transfection, the turnover of palmitate was slower on alpha i1...

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PMID: 7983022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Palmitoylation of a G protein alpha i subunit requires membrane localization not myristoylation.PMID 7983022Read ↗

Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.Semantic proximity Read ↗

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Cysteine 3 is not the site of in vitro palmitoylation on G(salpha).Semantic proximity Read ↗

Targeting of a G alpha subunit (Gi1 alpha) and c-Src tyrosine kinase to caveolae membranes: clarifying the role of N-myristoylation.Semantic proximity Read ↗

G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.Semantic proximity Read ↗

Coordinated agonist regulation of receptor and G protein palmitoylation and functional rescue of palmitoylation-deficient mutants of the G protein G11alpha following fusion to the alpha1b-adrenoreceptor: palmitoylation of G11alpha is not required for interaction with beta*gamma complex.Semantic proximity Read ↗

The 5-hydroxytryptamine(1A) receptor is stably palmitoylated, and acylation is critical for communication of receptor with Gi protein.Semantic proximity Read ↗

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Enrichment of G-protein palmitoyltransferase activity in low density membranes: in vitro reconstitution of Galphai to these domains requires palmitoyltransferase activity.Semantic proximity Read ↗

N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q).Semantic proximity Read ↗

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