Article
Palmitoylation influences the function and pharmacology of sodium channels.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2011
Bosmans Frank, Milescu Mirela, Swartz Kenton J
Abstract excerpt
Palmitoylation is a common lipid modification known to regulate the functional properties of various proteins and is a vital step in the biosynthesis of voltage-activated sodium (Nav) channels. We discovered a mutation in an intracellular loop of rNav1.2a (G1079C), which results in a higher apparent affinity for externally applied PaurTx3 and ProTx-II, two voltage sensor toxins isolated from tarantula venom. To...
Topics
- Animals
- Cholesterol
- Cysteine
- Intracellular Space
- Ion Channel Gating
- Lipoylation
- Mutant Proteins
- Mutation
- NAV1.2 Voltage-Gated Sodium Channel
- Nerve Tissue Proteins
- Rats
- Sodium Channels
- Spider Venoms
- Xenopus