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Article

Palmitoylation influences the function and pharmacology of sodium channels.

Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2011

Bosmans Frank, Milescu Mirela, Swartz Kenton J

Abstract excerpt

Palmitoylation is a common lipid modification known to regulate the functional properties of various proteins and is a vital step in the biosynthesis of voltage-activated sodium (Nav) channels. We discovered a mutation in an intracellular loop of rNav1.2a (G1079C), which results in a higher apparent affinity for externally applied PaurTx3 and ProTx-II, two voltage sensor toxins isolated from tarantula venom. To...

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Identifiers

PMID: 22123950
DOI: 10.1073/pnas.1108497108
PMCID: PMC3250191

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Source receipt: pubmed, retrieved 7 Sept 2026.

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