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Article

Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice.

Cancer research - 15 Aug 1998

Beamer W G, Shultz K L, Tennent B J, Nadeau J H, Churchill G A, Eicher E M

Abstract excerpt

Spontaneous juvenile ovarian granulosa cell (GC) tumors that occur in young girls are similar to GC carcinomas that develop in SWR-derived inbred mice. We analyzed female offspring from a series of matings among SWR and SJL inbred mice for chromosomal loci underlying tumor susceptibility. Intercross F2 female mice were produced by reciprocal matings of (SWR x SJL)F1 and (SJL x SWR)F1 parents. Tumorigenesis in...

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PMID: 9721880

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