Article
Mutations in toxR and toxS that separate transcriptional activation from DNA binding at the cholera toxin gene promoter.
Journal of bacteriology - 1 Sept 1998
Pfau J D, Taylor R K
Abstract excerpt
ToxR and ToxS are integral membrane proteins that activate the transcription of virulence genes in Vibrio cholerae. ToxR can be separated into three different domains: an N-terminal cytoplasmic DNA binding domain, a central transmembrane domain, and a C-terminal periplasmic domain. ToxS is though...
Topics
- Alleles
- Bacterial Proteins
- Base Sequence
- Cholera Toxin
- DNA, Bacterial
- DNA-Binding Proteins
- Gene Expression Regulation, Bacterial
- Membrane Proteins
- Mutagenesis, Site-Directed
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- Protein Binding
- Recombinant Proteins
- Salmonella typhimurium
- Selection, Genetic
- Transcription Factors
- Transcriptional Activation
- Vibrio cholerae