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Article

Role of ToxS in the proteolytic cascade of virulence regulator ToxR in Vibrio cholerae.

Molecular microbiology - 1 Dec 2015

Almagro-Moreno Salvador, Root Michael Z, Taylor Ronald K

Abstract excerpt

Two of the primary virulence regulators of Vibrio cholerae, ToxR and TcpP, function together with cognate effector proteins. ToxR undergoes regulated intramembrane proteolysis (RIP) during late stationary phase in response to nutrient limitation at alkaline pH; however, the specific function of its cognate ToxS remains unresolved. In this work, we found that ToxR rapidly becomes undetectable in a ΔtoxS mutant...

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PMID: 26316386
DOI: 10.1111/mmi.13170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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