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Article

The wing of the ToxR winged helix-turn-helix domain is required for DNA binding and activation of toxT and ompU.

PloS one - 1 Jan 2019

Morgan Sarah J, French Emily L, Plecha Sarah C, Krukonis Eric S

Abstract excerpt

ToxR and TcpP, two winged helix-turn-helix (w-HTH) family transcription factors, co-activate expression of the toxT promoter in Vibrio cholerae. ToxT then directly regulates a number of genes required for virulence. In addition to co-activation of toxT, ToxR can directly activate the ompU promoter and repress the ompT promoter. Based on a previous study suggesting that certain wing residues of ToxR are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31498842
DOI: 10.1371/journal.pone.0221936
PMCID: PMC6733452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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