OmpR mutants specifically defective for transcriptional activation.

doi:10.1016/0022-2836(94)90033-7

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Article

OmpR mutants specifically defective for transcriptional activation.

Journal of molecular biology - 4 Nov 1994

Pratt L A, Silhavy T J

Abstract excerpt

In Escherichia coli, OmpR and EnvZ comprise a two component regulatory system that controls the relative expression of the outer membrane porin proteins, OmpF and OmpC. In this system, OmpR functions as a transcriptional regulator, serving as an activator of ompC, and as both an activator and a repressor of ompF. Previous evidence suggests that OmpR-mediated transcriptional activation involves direct interaction...

Topics

Alleles
Bacterial Outer Membrane Proteins
Bacteriophages
Base Sequence
DNA, Bacterial
DNA-Binding Proteins
DNA-Directed RNA Polymerases
Diploidy
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Multienzyme Complexes

Mutagenesis, Site-Directed

Oligonucleotides

Plasmids

Polymerase Chain Reaction

Porins

Source

Open in PubMed

Identifiers

PMID: 7966283
DOI: 10.1016/0022-2836(94)90033-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7966283-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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OmpR mutants specifically defective for transcriptional activation.PMID 7966283Read ↗

Gene activation by the Escherichia coli positive regulator OmpR: a mutational study of the DNA-binding domain of OmpR.Semantic proximity Read ↗

Mechanism of gene activation by the Escherichia coli positive regulator, OmpR: a mutant defective in transcriptional activation.Semantic proximity Read ↗

Gene activation by the Escherichia coli positive regulator, OmpR. Phosphorylation-independent mechanism of activation by an OmpR mutant.Semantic proximity Read ↗

Suppressor mutations in rpoA suggest that OmpR controls transcription by direct interaction with the alpha subunit of RNA polymerase.Semantic proximity Read ↗

Mutations in a central highly conserved non-DNA-binding region of OmpR, an Escherichia coli transcriptional activator, influence its DNA-binding ability.Semantic proximity Read ↗

cis-acting ompF mutations that result in OmpR-dependent constitutive expression.Semantic proximity Read ↗

Identification of base pairs important for OmpR-DNA interaction.Semantic proximity Read ↗

A phosphorylation site mutant of OmpR reveals different binding conformations at ompF and ompC.Semantic proximity Read ↗

The linker region plays an important role in the interdomain communication of the response regulator OmpR.Semantic proximity Read ↗

Mutations in the alpha subunit of RNA polymerase that affect the regulation of porin gene transcription in Escherichia coli K-12.Semantic proximity Read ↗

Amino acids important for DNA recognition by the response regulator OmpR.Semantic proximity Read ↗

A single amino acid substitution in the C terminus of OmpR alters DNA recognition and phosphorylation.Semantic proximity Read ↗

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