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Article

Deleterious mutations show increasing negative effects with age in Drosophila melanogaster.

BMC biology - 30 Sept 2020

Brengdahl Martin I, Kimber Christopher M, Elias Phoebe, Thompson Josephine, Friberg Urban

Abstract excerpt

BACKGROUND: In order for aging to evolve in response to a declining strength of selection with age, a genetic architecture that allows for mutations with age-specific effects on organismal performance is required. Our understanding of how selective effects of individual mutations are distributed across ages is however poor. Established evolutionary theories assume that mutations causing aging have negative...

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PMID: 32993647
DOI: 10.1186/s12915-020-00858-5
PMCID: PMC7526172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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