Article
Mutation and the evolution of ageing: from biometrics to system genetics.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 27 Apr 2010
Hughes Kimberly A
Abstract excerpt
A notable success for evolutionary genetics during the past century was to generate a coherent, quantitative explanation for an apparent evolutionary paradox: the tendency for multicellular organisms to show declining fitness with age (senescence, often referred to simply as 'ageing'). This general theory is now widely accepted and explains most of the features of senescence that are observed in natural and...
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