Article
Inferences on genome-wide deleterious mutation rates in inbred populations of Drosophila and mice.
Genetica - 1 Jan 1998
Caballero A, Keightley P D
Abstract excerpt
A theoretical analysis was carried out on the mutation load observed in long-maintained inbred lines from two experiments with Drosophila and mice. The rate of decline in fitness and its sampling distribution were predicted for both experiments using Monte Carlo simulation with a range of mutational parameters and models. The predicted rates of change in fitness were compared to the empirical observed rates,...
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