Inferences on genome-wide deleterious mutation rates in inbred populations of Drosophila and mice.

Article

Inferences on genome-wide deleterious mutation rates in inbred populations of Drosophila and mice.

Genetica - 1 Jan 1998

Caballero A, Keightley P D

Abstract excerpt

A theoretical analysis was carried out on the mutation load observed in long-maintained inbred lines from two experiments with Drosophila and mice. The rate of decline in fitness and its sampling distribution were predicted for both experiments using Monte Carlo simulation with a range of mutatio...

Topics

Animals
Crosses, Genetic
Drosophila
Female
Inbreeding
Litter Size
Male
Mice
Mice, Inbred Strains
Models, Genetic
Monte Carlo Method
Mutation
Pupa
Regression Analysis
Selection, Genetic

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