Inference of genome-wide mutation rates and distributions of mutation effects for fitness traits: a simulation study.

Abstract excerpt

The properties and limitations of maximum likelihood (ML) inference of genome-wide mutation rates (U) and parameters of distributions of mutation effects are investigated. Mutation parameters are estimated from simulated experiments in which mutations randomly accumulate in inbred lines. ML produ...

Topics

• Animals
• Computer Simulation
• Genome
• Humans
• Models, Genetic
• Models, Theoretical
• Mutation