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Article

Spontaneous mutations and the origin and maintenance of quantitative genetic variation.

eLife - 23 May 2016

Huang Wen, Lyman Richard F, Lyman Rachel A, Carbone Mary Anna, Harbison Susan T, Magwire Michael M, Mackay Trudy Fc

Abstract excerpt

Mutation and natural selection shape the genetic variation in natural populations. Here, we directly estimated the spontaneous mutation rate by sequencing new Drosophila mutation accumulation lines maintained with minimal natural selection. We inferred strong stabilizing natural selection on quantitative traits because genetic variation among wild-derived inbred lines was much lower than predicted from a neutral...

Read the complete abstract on PubMed

Topics

Animals
Drosophila
Genetic Variation
Mutation Accumulation
Mutation Rate
Quantitative Trait Loci

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Selection, Genetic

Source

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Identifiers

PMID: 27213517
DOI: 10.7554/eLife.14625
PMCID: PMC4929002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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